A Wildtype GIST Clinic has been announced by the National Institutes of Health, USA. The upcoming “Pediatric and Wildtype GIST Clinic” at the NIH is scheduled for June, 10th-12th, 2015. There are spots available for [...]
The 12th Pediatric and Wildtype GIST Clinic was held May 21 to 23, 2014 at the National Institutes of Health in Bethesda, Maryland. Coordinated by Dr. Sosipatros Boikos, and based out of the NIH Pediatric Oncology Department under the direction of Dr. Lee Helman, the Clinic is collaboration between clinicians and researchers to collect data, investigate and develop treatment for GIST patients who do not have either c-KIT or PDGFRA mutation.
Written by Jennifer Wright April, 2011 - This article is a summary of “Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations” in the Proceedings of the National Academy of Sciences [...]
Researchers at Memorial Sloan-Kettering Cancer Center (MSKCC) in New York have found a rare mutation in some GIST tumors. In a series of 61 patients with wild-type GIST, they found that three of them (5%) had mutations in a gene called BRAF. This same mutation, a “V600E” mutation in exon 15 of the BRAF gene, occurs frequently in melanoma. They also found the same mutation in one of 28 GIST patients that were resistant to Gleevec.
Dr. Andrew Godwin, a researcher at Fox Chase Cancer Center in Philadelphia, Penn., presented data at the 2008 American Society of Clinical Oncology conference (ASCO) indicating that the Insulin-like Growth Factor 1 Receptor (IGF-1R) [...]