There are a number of types of GIST. Less than 20 years ago, GIST was a disease frequently misdiagnosed – usually as leiomyosarcoma. Today, not only can we use immunohistochemistry to diagnosis GIST, but also to identify several subtypes. With mutational testing, these subtypes can further be broken down by gene mutation and exon. Identifying your mutation means that your GIST experts can individualize treatment giving you the most effective treatment available for your type of GIST.
Consulting with a GIST expert after your diagnosis is the most effective way to gain the most up-to-date knowledge and best treatment plan for your GIST. You can find more information on specialists with our GIST Specialists Database or call The Life Raft Group at 973-837-9092.
Adult GIST, the most common type of GIST, can occur anywhere in the GI tract and is most commonly diagnosed in older adults. Response to medications can vary by mutation type (KIT, PDGFRA, Wildtype) and mutation location (exon 9, 11, etc.). For example, the PDGFRA D842V mutation is completely resistant to Gleevec and Sutent.
With mutational testing, these subtypes can further be broken down by gene mutation and exon. Identifying your mutation means that your GIST expert can individualize treatment giving you the most effective treatment available for your type of GIST.
Clinical trials are available for resistant (advanced) GIST patients with the D842V mutation, both as first-line therapy and for patients that have had Gleevec or Sutent.
Resources to help manage your GIST care and education
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