Josalin Dunn is not your average 8-year-old girl. It’s not because she comes from a family of seven children. It is not because she has cancer. It is because she has remained bright-eyed and optimistic — despite the twists and turns she has had to endure during her young life in Fort Meyers, Fla.
Results from a Continuation Trial of SU11248 in Patients with Imatinib-Resistant Gastrointestinal Stromal Tumor (GIST)
Here are the trial results from a Continuation Trial of SU11248 in Patients with Imatinib-resistant GIST.
SU11248 is similar to Gleevec in the way it works. It is a small molecule inhibitor of the receptor tyrosine kinases PDGFRA, VEGFR, KIT and FLT3. For patients with KIT or PDGFRA mutations, the main targets of this drug are still KIT and PDGRFA. SU11248 also inhibits VEGFR. This provides an anti-angiogenic effect in addition to the primary anti-tumor effect. All tumors need new blood vessels (angiogenesis) in order for tumor growth to occur; treatments that block the growth of these new blood vessels are called “anti-angiogenesis” treatments.
Clinical trials have given us a lot of information about dosing Gleevec. Unfortunately, however, doctors and researchers do not always reach the same conclusions about what the data is telling them. Measuring Gleevec drug levels in patients may provide a measure of reassurance to patients and doctors that they are on the right course with regards to dosing.
GIST — Gastrointestinal stromal tumor. To doctors, this is a rare tumor that is usually found in the stomach. To me, a 15-year-old girl, it is something that has changed my life in so many ways. Growing up, I was always a healthy girl. I never got the flu or even a cold. Whenever I even fell and scratched my knee, I would get right back up and put a Band-Aid on it.
She was born March 20, 1948 in Pauls Valley, Okla. She attended Maysville public schools where she was a majorette. At the University of Oklahoma, she graduated in 1970 with a degree in piano performance. After raising a family, she returned to college and obtained her degree in accounting from the University of Central Oklahoma.
I’ve had GIST for 3 1/2 years, since I was 15; I was diagnosed on the 23rd December (not the best date to pick). I was also in the middle of my last year of school and 5 months away from my final exams (In England the school system goes to 16 and then you have your Gcse exams, which are your final exams). They announced my diagnosis in a school assembly to make sure that everyone had the facts. My oncology nurse went to talk to them. I knew about it beforehand and thought it was a good idea, instead of people not being sure about it and making rumours. My friends didn’t react very well.
Leigh Borland was at her lowest point. On November 14, 2005 she had gone into the hospital for a hysterectomy. The doctors thought they had found a mass on her ovaries. What they actually found was a 5-6 cm primary tumor on her colon and two smaller tumors nearby; the pathology report listed it as “unknown malignant potential.” The oncologist decided to send slides out to the Cleveland Clinic and got a GIST confirmation.